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University endowments are one of the key nexuses by which finance influences the future of science, tech, and the human condition, and what happens at endowments and other limited partners (LPs) matters deeply both for their clients but also the wider VC asset class. Washington University in St. Louis Chief Investment Officer Scott Wilson, who drove the university’s record-breaking 65% return last year and is also a Lux LP, joins the podcast to discuss how he redeemed $3.6 billion in assets his first week on the job in 2017, his origin story in rural Alaska, and WashU’s strategy of direct investing alongside its GPs. We then also discuss the global macro environment, crypto markets, the future of healthcare investing, as well as some book recommendations.

How permanent should software be?